Nektar Therapeutics is a clinical-stage biopharmaceutical company which develops a pipeline of drug candidates that utilize company platforms. The Company's product pipeline is consisted of early to late stage drug candidates across a number of therapeutic areas, including oncology, pain, anti-infectives, anti-viral and immunology. Its research and development activities involve both small molecule and biologic drug candidates. It creates drug candidates by using its advanced polymer conjugate technologies to modify the chemical structure of pharmacophores to create new molecular entities. Its drug candidate, naloxegol (formerly known as NKTR-118), is an oral opioid antagonist, which has completed Phase III clinical studies for the treatment of opioid-induced constipation (OIC) in patients with non-cancer pain. Its second drug candidate, etirinotecan pegol (also known as NKTR-102), is a topoisomerase I inhibitor, which is under Phase III clinical study as of December 31, 2012.